To protect optimal functionality of the Vanquish system, observe these recommendations on the use of solvents and additives:
The system must be used with reversed-phase (RP) compatible solvents and additives only.
Use only solvents and additives that are compatible with all parts in the flow path.
Anhydrous methanol may lead to stress failures in titanium surfaces, especially when formic acid or TFA is added to the mixture. Thermo Fisher Scientific recommends adding 3% of water to prevent this.
TIP
In a Vanquish Core system, normal-phase (NP) compatible solvents and additives may be used if the system modules have been modified for NP applications. Refer to the Vanquish System Operating Manual.