To protect optimal functionality of the Vanquish system, observe these recommendations on the use of solvents and additives:

  • The system must be used with reversed-phase (RP) compatible solvents and additives only.

  • Use only solvents and additives that are compatible with all parts in the flow path.

  • Anhydrous methanol may lead to stress failures in titanium surfaces, especially when formic acid or TFA is added to the mixture. Thermo Fisher Scientific recommends adding 3% of water to prevent this.

TIP

In a Vanquish Core system, normal-phase (NP) compatible solvents and additives may be used if the system modules have been modified for NP applications. Refer to the Vanquish System Operating Manual.