Use seal wash liquid that fulfills the following requirements:

  • The seal wash liquid is miscible with the solvent that is used in the pump.

  • The seal wash liquid is compatible with the seal wash tubing.

  • The seal wash liquid provides certain conductivity for reliable performance of the seal wash detector.

    • HPLC-grade water with 10% methanol is an appropriate choice.

    • With a Vanquish Core system that has been modified for NP applications, the appropriate liquid depends on the application:
      NP application:
      Use ammonium formate in isopropanol (2 mmol/L).
      RP application:
      Use HPLC-grade water with 10% methanol.