Preparing the System for Operation - Vanquish Neo UHPLC - Vanquish Neo System (VN-A10, VN-C10, VN-P10, VN-S10) Operating Manual - Preparing the System for Operation - Operation - Vanquish Neo UHPLC

Vanquish Neo System (VN-A10, VN-C10, VN-P10, VN-S10) Operating Manual
Product Tree
Chromatography > Liquid Chromatography > Vanquish Series > Vanquish Neo UHPLC
Document Type
Operating Manual
  • Vanquish Neo System
  • Using this Manual
  • About this Manual
  • Conventions for Safety Messages
  • Special Notices
  • Typographical Conventions
  • Reference Documentation
  • Safety
  • Safety Symbols and Signal Words
  • Safety Symbols and Signal Words in this Manual
  • Observing this Manual
  • Safety Symbols on the System
  • Rating Plates
  • Intended Use
  • Safety Precautions
  • General Safety Information
  • Qualification of the Personnel
  • Personal Protective Equipment
  • Electrical Safety Precautions
  • General Residual Hazards
  • In Case of Emergency
  • Compliance Information
  • System Overview
  • System Features
  • System Description
  • System Base
  • System Base Parts
  • System Base Lock
  • System Controller
  • Pump
  • Pump Interior Components
  • Pump Operating Principle
  • Autosampler
  • Autosampler Interior Components
  • Autosampler Operating Principle
  • Port Assignments of the Autosampler Valves
  • Sample Compartment
  • Sample Compartment Thermostatting
  • Carousel
  • Rack Type Identification
  • Column Compartment
  • Column Compartment Interior Components
  • Column Compartment Operating Principle
  • Column Switching Valve Overview
  • Solvent Rack
  • Leak Detection
  • Needle Wash System (Overview)
  • Seal Wash System (Overview)
  • Power On/Off Control
  • Operation of the System
  • Purging (Overview)
  • Unpacking
  • Damaged Packaging, Defective on Arrival
  • Scope of Delivery
  • Unpacking the System
  • Unpacking the Column Compartment
  • Unlocking the System Base
  • Installation
  • Safety Guidelines for Installation
  • Site Requirements
  • Workbench
  • Power Considerations
  • Power Cord
  • Condensation
  • Operating Conditions
  • Installing the System
  • Opening and Closing the Front Doors
  • Installing the Column Compartment
  • Placing the Column Compartment in the System Stack
  • Installing the Vanquish Switching Valve
  • Installing the VICI Switching Valve
  • Installing the Passive Pre-Heater
  • Installing Columns in the Column Compartment
  • Removing Transport Protections from the Autosampler
  • Removing the Insulation Cover
  • Installing the Insulation Cover
  • Mounting the Display
  • Connecting Cables
  • System Module Connector Overview
  • System Controller Connector Overview
  • Connecting USB Cables
  • Connecting the Display Cables
  • Connecting System Interlink Cables
  • Connecting a LAN Cable
  • Connecting Power Cords
  • Guiding Signal Cables in the Cable Clips
  • Connecting a Mass Spectrometer
  • Locking the System Base
  • Setting Up the Flow Connections
  • Guiding Capillaries and Tubing Through the System
  • Connecting Fittings, Capillaries, and Tubing
  • General Guidelines
  • Connecting NanoViper Capillaries
  • Connecting the Waste Lines
  • Waste Connections Overview
  • Connecting the Drain Tubing to the System Drain Port
  • Testing the Drain System
  • Filling the Solvent Reservoirs
  • Filling the Needle Wash Reservoirs
  • Filling the Seal Wash Reservoir
  • Turning On the System for the First Time
  • Integrating into an Instrument LAN
  • Preparing the System for Initial Operation
  • Operation
  • Safety Guidelines for Operation
  • Solvent and Additive Information
  • General Compatibility
  • Allowed pH Ranges
  • Allowed Concentrations
  • Use of Solvents and Additives
  • General Guidelines for System Operation
  • Turning On the System
  • Control Elements
  • Keypads
  • LED bars
  • Vanquish User Interface Overview
  • System Controller Information
  • Overall System Health Status Icons
  • Navigation Bar Icons and Other Icons
  • Operational Status of the System
  • Home Panel
  • Script Panel
  • Settings Panel
  • Adjusting the Display
  • Possible Display Positions
  • Moving the Display from the Front Position to the Lateral Position
  • Preparing the System for Operation
  • Flushing the System
  • Equilibrating the System
  • Loading the Carousel
  • Recommendations on Vial Caps and Well Plate Covers
  • Optimizing the Performance
  • Dependency of Available Pump Pressure and Flow Rate
  • Adding Custom Solvents to the Calibration Table
  • Changing the Solvent Type
  • Changing the Seal Wash Liquid
  • Changing the Needle Wash Liquid
  • Adjusting the Pump Flow Sensor Offsets
  • Washing the Needle
  • Thermostatting the Autosampler Sample Compartment
  • Thermostatting the Column Compartment
  • Shutting Down the System
  • Interrupting Operation of the System for a Short Period
  • Interrupting Operation of the System for a Longer Period
  • Maintenance and Service
  • Introduction to Maintenance and Service
  • Safety Guidelines for Maintenance and Service
  • General Rules for Maintenance and Service
  • Routine and Preventive Maintenance
  • Maintenance Plan
  • Weekly Maintenance
  • Regular Maintenance
  • Annual Maintenance
  • Flushing the Pump to Avoid Contamination
  • Flushing the Pump with Persistent Contamination Only
  • Cleaning or Decontaminating a System Module or the System
  • Pump Head Maintenance
  • Overview of Pump Head Parts
  • Replacing the Pump Head
  • Removing the Pump Head
  • Installing the Pump Head
  • Replacing the Pistons
  • Removing the Pistons
  • Installing the Pistons
  • Cleaning the Piston
  • Replacing the Support Ring
  • Removing the Support Ring
  • Installing the Support Ring
  • Replacing the Piston Seal
  • Removing the Piston Seal
  • Installing the Piston Seal
  • Replacing the Seal Wash Seal
  • Removing the Seal Wash Seal
  • Installing the Seal Wash Seal
  • Replacing the Pump Head Seals
  • Removing the Pump Head Seals
  • Installing the Pump Head Seals
  • Maintaining the Pump Head Check Valves
  • Replacing the Inlet Check Valve (Pump Head)
  • Replacing the Outlet Check Valve (Pump Head)
  • Cleaning the Check Valves (Pump Head)
  • Flowmeter Maintenance
  • Replacing the Flowmeter Filter
  • Replacing the Flowmeter Waste Line
  • Solvent Line Maintenance
  • Emptying the Solvent Lines
  • Replacing Solvent Lines from Reservoir to Pump
  • Replacing Solvent Lines from Shut-off Valve to Pump Head
  • Replacing the Solvent Line Filter
  • Sample Loop Maintenance
  • Components of the Sample Loop
  • Removing the Sample Loop
  • Installing the Sample Loop
  • Completing the Sample Loop Replacement
  • Needle Unit Maintenance
  • Components of Needle Unit and Needle Seat
  • Securing the Needle Unit
  • Unlocking the Needle Unit
  • Replacing Needle Seat and Needle Unit
  • Replacing Needle Seat
  • Replacing Needle Unit
  • Completing the Needle Seat and Needle Unit Replacement
  • Metering Device Head Maintenance
  • Components of the Metering Device Head
  • Disconnecting and Connecting Metering Device Head Capillaries
  • Replacing the Metering Device Head
  • Drain Pump Maintenance
  • Testing the Drain Pump Tubing
  • Replacing the Drain Pump Tubing
  • Needle Wash System Maintenance
  • Replacing Wash Lines from Reservoir to Needle Wash Pump Inlet
  • Replacing Wash Line from Needle Wash Pump Outlet to Wash Port
  • Replacing Wash Lines from Reservoir to Degasser Inlet Ports
  • Replacing Wash Lines from Degasser Outlet Port to the Selector Valve
  • Replacing the Needle Wash Check Valve
  • Seal Wash System Maintenance
  • Testing the Seal Wash System for Leakage
  • Replacing the Seal Wash Reservoir Line
  • Replacing the Seal Wash Inlet Line
  • Replacing the Seal Wash Pump Inlet Line
  • Replacing the Peristaltic Tubing in the Seal Wash Pump
  • Replacing the Seal Wash Lines between Seal Wash Pump and Seal Wash Detector
  • Replacing the Seal Wash Detector
  • Inspecting the Autosampler Valves for Leakage
  • Column Compartment Maintenance
  • Replacing Columns
  • Inspecting the Column Switching Valves for Leakage
  • Replacing the Vanquish Switching Valve
  • Replacing the VICI Switching Valve
  • Replacing the VICI Switching Valve Stator and/or Rotor Seal
  • Replacing the Passive Pre-Heater
  • System Controller and Display Maintenance
  • Replacing the System Controller
  • Removing the System Controller
  • Installing the System Controller
  • Connecting the System Controller
  • Replacing the SD Card
  • Replacing the Display
  • Unmounting the Display
  • Solvent Rack Replacement
  • Bottle Insert Replacement
  • Removing the Bottle Insert
  • Installing the Bottle Insert
  • Main Power Fuse and Door Replacement
  • Replacing the Main Power Fuses
  • Replacing the Doors
  • Replacing the Slide-In Module
  • Preparing the Pump for Removal
  • Removing the Pump Slide-In Module
  • Preparing the Autosampler for Removal
  • Removing the Autosampler Slide-in Module
  • Preparing the Column Compartment for Removal
  • Removing the Column Compartment Slide-In Module
  • Returning the Slide-In Module
  • Installing the Slide-In Module
  • Preparing the System for Transport
  • Fixing the Carrying Handles
  • Troubleshooting
  • General Information about Troubleshooting
  • Messages
  • Common Messages
  • Pump Messages
  • Autosampler Messages
  • Column Compartment Messages
  • System Troubleshooting
  • Peaks
  • Peak Shape
  • Ghost Peaks, Negative Peaks and Spikes
  • Peak Area Precision
  • Pressure
  • Retention Time Variation
  • Baseline
  • Increased Loading Time of the Trap Column
  • Temperature Control
  • Column Compartment Temperature Control Problems
  • Autosampler Temperature Control Problems
  • Power and Communication (System Modules)
  • System Controller, Display, and User Interface related Problems
  • Testing for Liquid Leaks
  • Specifications
  • Physical Specifications
  • Environmental Specifications
  • Power Requirements
  • Dimensions
  • Emission Sound Pressure Level
  • Weight
  • Performance Specifications
  • System Performance Specifications
  • Pump Performance Specifications
  • Autosampler Performance Specifications
  • System Controller Performance Specifications
  • Column Compartment Performance Specifications
  • Accessories, Consumables and Replacement Parts
  • General Information
  • Ship Kit
  • System
  • Column Compartment
  • Optional Accessories
  • Consumables and Replacement Parts
  • Capillaries, Capillary Accessories and Drainage
  • System Replacement Parts and Tools
  • System Controller Replacement Parts
  • Solvents and Wash Systems
  • Pump Replacement Parts
  • Autosampler Replacement Parts
  • Column Compartment Replacement Parts
  • Interface Cables and Power Cords
  • Appendix
  • Compliance Information
  • Declarations of Conformity
  • WEEE Compliance
  • FCC Compliance
  • Manual Release History
  • Digital I/O (Pin Assignment)

This section gives information on any additional steps that are required to prepare the system for operation.

  1. Flush the system. See Flushing the System.

  2. Equilibrate the system. See Equilibrating the System.

  3. Load the carousel. See Loading the Carousel.

  4. Observe the recommendations on vial caps and well plate covers. See Recommendations on Vial Caps and Well Plate Covers.

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