To protect optimal functionality of the system, observe these recommendations on the use of solvents and additives:

  • Use only solvents and additives that are compatible with all parts in the flow path. For information about the materials that are used in the analytical flow path, see the Performance Specifications for each system module.

  • The material of the bottle insert is closed-cell expanded polypropylene that is compatible with most common HPLC solvents.

  • Anhydrous methanol may lead to stress failures in titanium surfaces, especially when formic acid or TFA is added to the mixture. Thermo Fisher Scientific recommends adding 3% of water to prevent this.

Piston Seal Compatibility

  • The pump is shipped with UHMW-PE piston seals. Using tetrahydrofuran, ketones, or ammonium hydroxide as solvents can damage the seals.

  • In rare cases, a shortened lifetime of reversed-phase (UHMW-PE) piston seals has been observed with high pH, ammonium hydroxide containing mobile phases and prolonged exposure.