The system comprises the following features:

Main Features

  • Pre-installed system offering high workflow versatility

  • Operating pressure of up to 150 MPa

  • Flow range from 100 nL/min to 100 µL/min

  • Integrated automated startup and purging functions

  • Continuous background system monitoring for minimized unplanned downtime

  • Diagnostic features for fast troubleshooting and increased uptime

  • Touch-based user interface, offering instrument monitoring and control and maintenance assistance

Specific Pump Features

  • Binary pump with each channel based on a serial dual-piston design

  • Floating piston design for compensation of small mechanical tolerances within the specification and thus enhanced robustness of the pump

  • One flowmeter supporting flow rates of 100 nL/min to 100 µL/min;
    no hardware change required except for system capillaries

  • Active seal wash system for high lifetime of pistons and piston seals

  • Automated purge valves for easy startup and diagnostics

  • Integrated automated startup and purging functions

  • Built-in automatic shut-off valves preventing solvent spillage and ensuring robust solvent aspiration

  • Built-in vacuum degasser for autosampler needle wash liquids

Specific Autosampler Features

  • Low carry-over split-loop injection principle featuring two needle wash liquids (weak and strong)

  • Washing inner needle, needle seat, and sample loop with weak and strong wash liquid

  • Washing outer needle surface with weak and strong wash liquid for minimum LCMS carry-over

  • Injection volumes up to 100 µL with one single stroke

  • Injection volumes higher than 100 µL through multi-draw feature for preconcentration of large volumes

  • Integrated automated startup and purging functions

  • Bottom sensing to allow aspiration of small volumes with minimal sample loss

  • Temperature control for thermostatting the sample compartment

  • Barcode reader inside the autosampler for identification of sample racks and well plates with barcodes for Vanquish rack type identification

  • Support of sample racks and well plates with a footprint as specified by the Society for Biomolecular Screening (SBS footprint)

  • Seal wash for metering device head for high lifetime of the seals

  • Integrated loading functionality

Specific Column Compartment Features

  • Column chamber (34 x 8 x 4 cm, w x h x d) providing room for columns, trap columns, and capillaries in various workflow setups

  • Space for up to two switching valves inside the column chamber for advanced applications

  • The column chamber and the components inside the chamber can be thermostatted over a wide temperature range with the minimum temperature being 5 °C above ambient temperature and the maximum temperature being 80 °C without valves or 60 °C with Vanquish Neo low-dispersion (LD) valves

  • Optimized design enabling an even air flow and heat distribution

  • Fast heat-up time (35 °C to 65 °C ±1 °C in less than 12 minutes)

  • Advanced temperature control providing temperature stability of ±0.05 °C