To optimize the column compartment performance, consider the following general guidelines:

  • Use short connection capillaries.

  • Monitor the usage of specific column compartment components, for example, column switching valves that are subject to wear and stress and schedule appropriate maintenance intervals (see Predictive Performance).

  • Always close the column chamber cover and the column compartment door during operation.

  • Observe the general guidelines and recommendations on the use of solvents and additives in the chromatography system. Refer to Use of Solvents and Additives in the Vanquish System Operating Manual.