• Use only volatile mobile phases. All constituents, i.e. solvents and additives, of the mobile phase should be sufficiently volatile to allow evaporation under the conditions used.

  • Non-volatile solutes in the mobile phase, even at trace amounts, produce a detector signal (background current, noise, drift). Minimize their concentration.

  • TIP

    A careful consideration in the selection of the mobile phase components will be helpful in minimizing the baseline noise and optimizing the performance during analysis.

  • Consider other possible sources of mobile phase and eluent contamination.

    Examples: Labware, pH electrodes, columns and system components

    In many cases, it is preferable to use materials dedicated for use only with volatile mobile phases.

  • NP solvents: NP solvents are highly soluble in the gas and might condensate in the gas exhaust tubing.