The TSQ Series II MSs can operate in either the positive or negative ion polarity mode. You can obtain positive ion scans, negative ion scans, or when using polarity switching, a combination of positive and negative ion scans. The MS controls whether positive ions or negative ions are transmitted to the mass analyzer for mass analysis by changing the polarity of the voltage potentials applied to the API source, ion optics, and ion detection system.
The information obtained from a positive ion mass spectrum is different from, and complementary to, the information from a negative ion spectrum. Therefore, the ability to obtain both positive ion and negative ion mass spectra aids you in the qualitative analysis of your sample. You can choose the ion polarity mode and ionization mode to obtain maximum sensitivity for the particular analyte of interest.