The TSQ Endura MS and the TSQ Quantiva MS were the first generation of TSQ Series II mass spectrometers.

For the TSQ Endura MS, quadrupoles Q1 and Q3 are square arrays of circular rods. Quartz spacers act as electrical insulators between the rods and the supporting structure.

Figure Quadrupole Q1 or Q3 (TSQ Endura)

For the TSQ Quantiva MS, quadrupoles Q1 and Q3 are square arrays of precision-machined true hyperbolic rods with larger inter-rod spacing. Quartz spacers act as electrical insulators between the rods and the supporting structure.

Figure Hyperquad Q1 or Q3 (TSQ Quantiva)

Thermo Fisher Scientific made the following improvements to the Q1 and Q3 quadrupoles in the second generation of TSQ Series II mass spectrometers:

  • For the TSQ Quantis and TSQ Fortis mass spectrometers, adding a set of pre-filter and post-filter sections that carry only RF voltage improved the ion transmission from that of the first generation models.
  • For the TSQ Altis MS, the quadrupoles have a similar geometry to those in the TSQ Quantis and TSQ Fortis mass spectrometers with RF-only sections, but they also have fully hyperbolic surfaces and larger spacing between the rods.

In the current third generation of TSQ Series II mass spectrometers, Thermo Fisher Scientific has improved the accuracy and stability of the Q1 and Q3 quadrupoles in the TSQ Altis Plus MS by modifying their design and dimensions.