• Support for targeted (PRM, SureQuant™) and hybrid-DIA workflows
• New Minora Targeted Detector node for handling targeted high-resolution MS2 data
• New nodes, template workflows, and tables for visualization
• Expanded support for spectral library creation, filtering options, and export
• Create predicted peptide spectral libraries from peptide lists with the ability to filter libraries
• Support for MSP format export for use in Skyline
• Improvements for TMT™ 32plex and support for the Thermo Scientific™ Orbitrap™ Astral™ Zoom High Resolution mode
• Added control channel filters and reporter ion filters (processing and consensus workflows) to improve 32plex precision, improve the precision of Orbitrap Astral TMT data, as well as improve the support for TMT HR scans on the Orbitrap Astral Zoom
• Support for automated fractionated sample processing with Ardia
• Fractions processed individually can now be grouped as fractions
• New normalization options and protein abundance calculation
• Median and sample group-based normalization for TMT/LFQ
• New protein abundance estimates to improve protein quantification reproducibility for LFQ
• Improved protein FDR
• LPGF picked FDR improves Protein IDs for larger datasets