The Proteome Discoverer application requires a license. In addition, ensure that the system meets the minimum requirements listed in the following table.

System

Minimum requirements

Recommended

Computer

  • 2 GHz processor
  • 16 GB RAM
  • Video card and monitor capable of 1280 x 1024 resolution (XGA)
  • Screen resolution of 96 dpi
  • 75 GB available on drive C
  • NTFS format
  • Data system computer with Intel™ Xeon™ dual 8- or 12-core processors, 3.2 GHz
  • 64 GB RAM
  • Video card and monitor capable of 2048 x1192 resolution (FHD)
  • 1 TB available on drive C (SSD drive)
  • 2 TB available on data drive (SSD drive)
  • NTFS format
  • CPU with AVX2-compatible (Advanced Vector Extensions 2) instruction set

Software

  • Adobe™ Reader™ 10 and later
  • Microsoft Windows 10, Windows 10 Enterprise, or Windows 11
    • 64-bit operating system for the Proteome Discoverer application
    • 32- or 64-bit operating system for the Proteome Discoverer Daemon utility
  • Microsoft .NET Framework 4.8, Microsoft .NET Runtime 7.0.10, ASP .NET Core Runtime 7.0.10

Same as minimum requirements

MascotSM Server

  • Mascot Server 2.1
    • Mascot servers running version 2.2 are usable, but retrieving the result files (protein sequences) from the servers can be a lengthy process because you can only retrieve the protein sequences one at a time.
    • Mascot servers running version 2.1 should have all available updates, patches, or both from Matrix Science already installed. Ensure that you have installed a patch that enables MIME format for the result files; otherwise, the Proteome Discoverer application cannot receive the search results from the Mascot server.

Same as minimum requirements

NOTE

Ensure that port 28199 is not blocked by firewalls.

NOTE

Before installing the Proteome Discoverer application, ensure that the Windows operating system has the Microsoft .NET Framework and Windows updates installed.