ProSightPD Database Manager gives you flexibility when creating a database to search their top-down data. The Database Manager allows you to easily build databases from any UniProt formatted .fasta, .xml file, or Proteome Discoverer formatted .mzIdentML file. After these files are imported into the database manager, you can add or remove sequences, edit sequences, and precisely annotate the database with proteoform level control using ProSight Annotator (previously Protein Annotator.)

You can download protein sequences, groups of protein sequences, and full proteome sequence databases from:

The ProSightPD application creates and stores databases as .psdb files. The Database Manager can convert the XML and FASTA files to PSDB format.