The table below lists all known issues that exist in the Orbitrap Exploris Series 4.3 Instrument Control Software release.

Table Known Issues

ID

Severity

Title

153093

3 - Medium

Divert Valves need to be Configured for USB Control.
Remedy: The divert valves can be controlled through interfacing with a computer. Download the MX Series II™ Control Software Program to configure the divert valves for Orbitrap Exploris: www.idex-hs.com/literature-tools/software-drivers/

153505

3 - Medium

Installer blocks workstation installation (Method Editor standalone) if there is already a Full Installation on the data system PC.
Remedy: Run Workstation installation on a different computer. Installer supports simultaneous Workstation installation of all Orbitrap Exploris instrument models.

153665

3 - Medium

Orbitrap Exploris 480 DVD ISO image: Software Uninstallation Error.

154441

3 - Medium

Tune: Display imperfect on 4 k monitor.

153627

3 - Medium

Tune: Under certain conditions, wrong number of errors and warnings is shown.

332442

4 - Low

Tune Preferences: Self-Calibration check box is enabled by default after upgrade from Orbitrap Exploris version 4.1 to 4.2.
Remedy: Deselect the check box in Tune Options > Tune Preferences > Self-Calibration Options. New installations are not affected.

153432

2 - High

UI: Method Editor: MIPS filter incompatible with Targeted Mass filter.
Remedy: Do not use MIPS Filter with Targeted Mass Filter.

214267

3 - Medium

Chromeleon: sporadic communication loss to Thermo Exploris Series ePanels.
Remedy: This may happen sporadically during standby or after a sequence has finished. Restarting Chromeleon allows regain control of Thermo Exploris Series ePanel.

280624

3 - Medium

MongoDB needs to be uninstalled manually when downgrading from Orbitrap Exploris Series 4.2 to an older version.

Uninstallation instruction:
Right-click MongoDBUninstaller.exe and choose Run as administrator.

Prerequisites

  1. To also uninstall MongoDB data and log files:

Procedure

  1. Open command prompt in administrator mode.
  2. Go to folder containing copied uninstaller.
  3. Run MongoDBUninstaller.exe with argument “-f”, e.g. C:\Uninstall> MongoDBUninstaller -f.

233537

3 - Medium

Chromeleon periodically shuts down with a message “The target application domain has been unloaded.”
Remedy: Launch Chromeleon after shutdown. The sequence keeps on running without data loss.

357682

2 - High

Instrument Configuration: the “Wait for Temperatures to Stabilize checkbox” is not functional after an Instrument PC restart.
Remedy: Restart Instrument PC two times after enabling or disabling the configuration setting.

288280

3 - Medium

Method Editor: Template methods cannot be saved after saving a number of methods previously.
Remedy: Restart the Method Editor.

769342

3 - Medium

Method Editor: Targeted Mass Filter with an empty Mass List Table leads to ME to crash/to not be functional when trying to clear or create a new method.

337356

3 - Medium

System Templates: ME: Chromeleon doesn't apply method settings from the template.
Remedy: In Chromeleon environment, use the ion source settings from the system template.

492317

3 - Medium

Installation of Orbitrap Exploris Series Instrument Control Software blocked on instrument PC with a popup explaining the app cannot be checked (no internet connection) or recognized (internet connection).
Remedy: Right-click the .iso file, and then click Properties. In the General tab, under Security, make sure that Unblock is selected. Then proceed with software installation.

683124

3 - Medium

Customer/Tune: Favorites are not saved in the correct folder when upgrading from Exploris 4.2 SP4 to Exploris 4.3
Remedy: Copy the files from the Program Files location into the Program Data location.

749427

2 - High

Orbitrap Exploris driver 4.3: Unable to create instrument method with CM 7.3.2 MUc

758688

3 - Medium

Status Indicator doesn't turn red after Venting & Bakeout as supposed according fo Acceptance Criteria