The table below lists defect fixes in the Orbitrap Astral Series 2.0 SP1 Instrument Control Software release that were implemented since the Orbitrap Astral Series 2.0 Instrument Control Software release.
ID | Severity | Title |
|---|---|---|
Defect fixes | ||
823734 | 3 - Medium | Spray stability evaluation fails although spray was stable before start of the evaluation |
834056 | 3 - Medium | SureQuant and Hybrid DIA methods may not work properly with certain Peripheral settings |
820722 | 2 - High | Sequence execution interrupted due to MS response timeout. |
The table below lists new features, improvements and defect fixes in the Orbitrap Astral Series 2.0 Instrument Control Software release that were implemented since the Orbitrap Astral Series 1.1 Instrument Control Software release.
ID | Severity | Title |
|---|---|---|
New features | ||
488673 | — | Orbitrap Astral Zoom: Faster Ion Optics Switching: Higher acquisition rate with improved ion optics switching times |
740686 | — | Orbitrap Astral Zoom: Faster Ion Processor Timings: Higher acquisition rate due to faster ion transfer in the Ion Processor |
491850 | — | Orbitrap Astral Zoom: Pre-Accumulation: The user needs bent-flatapole pre-accumulation |
595718 | — | Orbitrap Astral Zoom: Application Mode: The user needs a "Low Input" Application Mode |
595715 | — | Orbitrap Astral Zoom: TMT 32-Plex: The user needs a TMT HR mode to resolve the signal of all reporter ions |
449007 | — | Orbitrap Astral Zoom: Peak Picking: The user needs Full Astral MS2 Spectrum Peak Picking |
491831 | — | Orbitrap Astral Zoom: SureQuant Hybrid DIA: The user needs to perform SureQuant type and derived Hybrid DIA acquisition using Astral analyzer |
747451 | — | Orbitrap Astral Zoom: Faster Stepped NCE in IRM: The user needs faster Astral MS2 acquisition when using stepped Collision Energy |
424340 | — | Orbitrap Astral Zoom: The user needs Top-Down Acquisition with Astral MS2 scans |
169738 | — | Orbitrap Astral Zoom: eDR: The user needs to perform eDR Full Scan-type ion detection |
650535 | — | Orbitrap Astral Zoom: tSIM msx: The user needs the ability to execute methods with multiplex tSIM with Orbitrap analyzer |
| ||
745468 | — | Astral MS2 Scan Range: The user needs expanded functionalities of Astral MS2 Scan Range |
745777 | — | System Calibrations must provide improved user experience |
749850 | — | Add "Exclude isotopic cluster" option to Targeted Mass Exclusion filter |
749864 | — | The user needs individual maxIT settings in DDA w/ inclusion list (directed-ddA) |
778704 | — | RAW File Scan Header: The user needs the ability to differentiate tMS2 and DIA scans via the scan header |
Defect fixes | ||
639247 | 3 - Medium | UI: ME: Orbitrap Astral Method Summary for DIA does not report the correct parameter used for Loop Control |
747865 | 3 - Medium | UI: ME: Factor 15 Rule is applied for Astral MS2 scan range unexpectedly |
784006 | 3 - Medium | UI: ME: RAW File Instrument Method erroneously reports Astral Resolution |
808914 | 3 - Medium | UI: XML Method Modification has dysfunctions |
639762 | 3 - Medium | After changing at setting in Tune, while the Instrument is in Intact Protein mode, Injection Time is unregulated |
631487 | 3 - Medium | Method Execution: nCE values are translated in CE values above 200 V |
763179 | 1 - Critical | RunStart ICS degrades mass accuracy |
776401 | 1 - Critical | Automatic Ion Foil Offset Adjustment leads to failing mass evaluations with large mass errors |
779710 | 4 - Low | Tune: Calibration and Diagnostics Start button - procedure "cancelled by user", after internal error |
The table below lists new features, improvements and defect fixes in the Orbitrap Astral Series 1.1 Instrument Control Software release that were implemented since the Orbitrap Astral Series 1.0 SP3 Instrument Control Software release.
ID | Severity | Title |
|---|---|---|
New features | ||
491821 | — | Stepped CE Astral: The user needs the ability to perform the acquisition of single MS2 scan with multiple Collision Energy values when using Astral detector Type |
425845 | — | Full Profile OT: The user needs the ability to perform Orbitrap MS1 and MS2 acquisition with Full Profile in Intact Protein Mode |
Improvements | ||
610911 | — | NSI: The user needs an updated default value of Positive Spray Voltage for NSI in ME and Tune |
431751 | — | Orbitrap Astral shall automatically correct the ion foil voltage using the ICS |
597081 | — | FAIMS CV switching performance shall be improved |
496128 | — | UI: ME: The user needs the "Lock mass injection" to be a parameter in the scan properties for each scan type |
407868 | — | Method Editor: The System Templates must be saved in "Astral" folder |
434211 | — | UI: ME: The user needs the possibility to choose "Use EASY-IC" On/Off for each experiment/scan type in Timed Mode |
469200 | — | UI: ME: The user needs to be able to see the displayed absolute AGC target values |
408025 | — | Tune: Favorites/UserSettings and History information must be saved in "Astral" folders |
448670 | — | The user needs the ability to monitor pressure readbacks for Astral Analyzer in Tune |
Defect fixes | ||
458725 | 3 - Medium | MongoDB uses large memory (>3GB) at background |
459860 | 3 - Medium | If in DIA experiments (using Astral detector) a Loop Time is defined, as shorter than the Orbitrap transient time set in another experiment of the method, the instrument schedules not enough DIA scans to match the expected loop control time |
594611 | 3 - Medium | Fluxscans are not used in edge cases (fm/lm +/- isolation width) |
597496 | 3 - Medium | DIA: Methods miswriting mass window centres as 524.265 in raw file instrument method |
598230 | 3 - Medium | Missing Plot: Mass Calibration |
591844 | 3 - Medium | Tune: Pressure Mode always set to Standard Pressure after startup |
592082 | 3 - Medium | Tune UI: Astral Turbo pumps readbacks are swapped |
467823 | 3 - Medium | Issue with DIA Windows Definition with Windows Optimization "On" under certain conditions |
470082 | 3 - Medium | Max IT information is not copied when using copy/paste functionality of MS2 information - instead default max IT (10 ms) is used |
439849 | 3 - Medium | "Use EASY-IC" dropdown is not available if LM correction mode is set to "timed" |
412392 | 2 - High | Instrument reported to be set to standby because of open source, but continued the sequence |
424847 | 3 - Medium | The search window for the EASY-IC lockmass is shifted by outliers |
426171 | 3 - Medium | "Bakeout cooling time" and other ICB/HICB timers are reset by software update |
415413 | 3 - Medium | Astral Mass Stabilization is performed at different timepoints within a LC-MS run |
455566 | 3 - Medium | Syringe does not get turned off during Electronics Smart Calibration in User System Calibration |
456040 | 2 - High | Setting the Funnel RF Level to default is not in Astral Default Scan Settings |
The table below lists defect fixes in the Orbitrap Astral Series 1.0 SP3 Instrument Control Software release that were implemented since the Orbitrap Astral Series 1.0 SP2 Instrument Control Software release.
Defect Fixes | ||
|---|---|---|
ID | Severity | Title |
466217 | 1 - Critical | Large Time Gap between MS1 and data-dependent MS2 scan. |
553186 | 2 - High | Insufficient IRM settling time causing unstable fragmentation pattern in Orbitrap MS2 scans. |
452322 | 1 - Critical | Ion Control not working well under low intensity, high background conditions. |
414707 | 3 - Medium | False positive initial bus error warnings from DPRTrap Board. |
427472 | 2 - High | Detector Calibration failing with “Too few ions in focused peak.” |
449905 | 2 - High | Suboptimal setting of channel saturation threshold. |
234095 | 2 - High | Astral analyzer pressure readbacks not displayed in Tune. |
The table below lists defect fixes in the Orbitrap Astral Series 1.0 SP2 Instrument Control Software release that were implemented since the Orbitrap Astral Series 1.0 SP1 Instrument Control Software release.
Defect Fixes | ||
|---|---|---|
ID | Severity | Title |
357681 | 4 - Low | Method execution waits for temperatures to stabilize while 'Wait for Temperatures to stabilize' option is unchecked in Instrument Configuration. |
361874 | 3 - Medium | Missing fields in the scan header/trailer. |
398882 | 3 - Medium | AGC calculations for method using more than one FAIMS CV (delta>1) are based on single CV. |
403091 | 3 - Medium | Raw file: Scan headers of ASTMS scans report irrelevant FT resolution. |
407881 | 3 - Medium | Data Acquisition using lock mass correction is not aborted while Internal Calibrant Source is faulty/defective. |
396718 | 1 - Critical | Data Acquisition: FAIMS occasionally returns “source is open” right after the start of a method while source is closed. |
416835 | 1 - Critical | Both the restart from an error as well as quick system restart fail with a restart loop. |
418457 | 1 - Critical | Orbitrap mode scan rate too low after reboot of system. |
424800 | 3 - Medium | Orbitrap easyIC lockmass correction (timed / Scan-to-Scan modes) is not functional if the first mass of the scan range is above m/z 275. |
424984 | 1 - Critical | Failing Signal Stability Evaluation - high TIC variations in Orbitrap signal. |
425564 | 3 - Medium | Bake-out plot is not redisplayed after the system entered standby. |
427904 | 3 - Medium | Block voltage insufficient for Curve Corrector on systems with large non-zero curve corrector settings. |
428554 | 3 - Medium | Activating microscans shifts the mass centroid in Astral spectra. |
429956 | 3 - Medium | TNG System Check Negative: system |
429981 | 3 - Medium | “Short burn-in of ICS” is always run during System Check. |
430132 | 3 - Medium | Previous plot is not redisplayed after Astral analyzer polarity switch. |
430259 | 1 - Critical | Discharge evaluation not actually setting to negative mode during discharge event. |
431767 | 3 - Medium | Missing Quick Gas Capillary Check to allow the user to assess if a capillary is blocked. |
433742 | 3 - Medium | Scan Start Timing fallback option may lead to out of order retention times. |
434485 | 3 - Medium | Missing checks in Tune Diagnostics. |
436967 | 3 - Medium | Astral service bundle mostly empty (no astral data). |
442099 | 2 - High | System Calibration: Quad RF DDS frequency does not get set always on boot. |
450428 | 1 - Critical | After performing Mass and System check from Tune, a drift of about 1 m/z unit may be observed in mass spectra acquired with Astral detector. |
The table below lists defect fixes in the Orbitrap Astral Series 1.0 SP1 Instrument Control Software release that were implemented since the Orbitrap Astral Series 1.0 Instrument Control Software release.
Defect Fixes | ||
|---|---|---|
ID | Severity | Title |
412822 | 1 - Critical | Occasionally spikes can be observed in ion chromatogram while ion spray stable. |
419732 | 1 - Critical | EASY-IC: Lockmass expected position does not change with polarity. |
421872 | 1 - Critical | XML method modification interface is not functional. |
419661 | 2 - High | System Calibration/Check: Change PrOSA Scaling specifications. |
416053 | 3 - Medium | System Calibration/Check: HCD Fragmentation and Trapping Efficiency Check leads to a SW internal failure (occasionally). |