Possible cause | Solution |
---|---|
Flow system leak; erratic baseline | Check for leaks in all tubing and fittings. Tighten all tubing connections and replace them as necessary. For tightening requirements, see Replace tubing and fittings. |
Trapped gases | Procedure
|
Pump not properly primed | Prime the pump (see Prime the analytical pump). |
Contaminated or incorrect eluent | Remake the eluent, using concentrated eluent and ASTM filtered, Type I (18.2-megohm-cm) deionized water that meets the specifications listed in Deionized water requirements for IC. |
Rapid changes in ambient temperature | Procedure
|
Insufficient system equilibration following changes to operating parameters; especially apparent when operating at high sensitivities | Allow a longer system equilibration time (up to 2 hours) before starting operation. |
Incorrect suppressor operating conditions | Refer to the suppressor manual for troubleshooting information. |
Cell above or below temperature | Contact Thermo Fisher Scientific Technical Support for assistance. |
Damaged piston seal | Replace the piston seal (see Remove and replace the pistons, analytical pump seals, and O-rings). |