Since solvents used with the Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate are added to ionic eluents to modify the ion exchange process or improve sample solubility, the solvents used must be free of ionic impurities. However, since most solvent manufacturers do not test for ionic impurities, the highest grade of solvents available should be used.

Currently, several manufacturers are making ultra-high purity solvents that are compatible with HPLC and spectrophotometric applications. These ultra-high purity solvents will usually ensure that your chromatography is not affected by ionic impurities in the solvent. Dionex has obtained consistent results using High Purity Solvents manufactured by Burdick and Jackson and Optima® Solvents by Thermo Fisher Scientific.