To create a new oligonucleotide sequence or edit an existing sequence, you can do any of the following:
- In the Sequence Manager, you can import an existing BioPharma sequence file (.sequencebpf) and then open the sequence in the Oligonucleotide Sequence Editor for editing.
- Open the Oligonucleotide Sequence Editor from the Sequence Manager and then import a FASTA file that contains the oligonucleotide sequence.
NOTE
The application cannot import the contents of a FASTA file that contains undefined oligo building blocks or an invalid format.
Before you open an unknown FASTA file, review its contents in a text editor such as Notepad.
If the FASTA file includes undefined building blocks, use the Oligo Building Block editor to create them before you import the file.
- Open the Oligonucleotide Sequence Editor from the Sequence Manager and then manually enter an oligonucleotide sequence.
After you enter the sequence and select its category, you can add static modifications and assign variable modifications to search against.