Within the default list of modifications, the BioPharma Finder application sets the modifications shown in the following table as a default sublist that you can quickly load to assign 5'-terminal, 3'-terminal, backbone linker, and 2'-ribose sugar group modifications to an oligonucleotide sequence.

Default sublist of modifications for quick loading

5’-terminal modifications:

Dephosphorylation

3’-terminal modifications:

Phosphorylation

Base modifications:

Adenine loss (A)

Uracil loss (U)

Cytosine loss (C)

Guanine loss (G)

Thymine loss (T)

Deamination (AC)

Oxidation (ACGU)

G Depurination (G)

U Depyrimidination (U)

C Depyrimidination (C)

T Depyrimidination (T)

I Depurination (I)

Acetyl group (AGC)

Benzoyl group (AC)

Isobutyl group (G)

Backbone linker modifications:

Cnet (ps)

Sulfur loss (s)

Phosphorothioate conversion (s)

2’-ribose modifications:

HF loss